SafeMinds has actively critiqued much of the research on the vaccine-autism link since 2000. Generation Rescue has provided two websites, fourteenstudies.org and putchildrenfirst.org, that provide critiques of the flaws of studies that are often used to refute the vaccine-autism link. Those websites include critiques written by SafeMinds, such as Analysis and Critique of the CDC’s Handling of the Thimerosal Exposure Assessment Based on VSD Information written as critique of the Verstraetten study. You will find other commentaries and critiques by SafeMinds below.
Urinary Excretion Study – SafeMinds Commentary (2/22/12)
Brief: Environment vs. Genetics
Why The Autism Epidemic Demands a New Approach
Background, Supporting Research and Analysis of Current Research Funding
Vaccines and Autism: What do Epidemiological Studies Really Tell Us?
This paper examines the epidemiological studies surrounding “autism and the MMR vaccine” and “autism and thimerosal”. It explains in detail the conflicts of interest, poor designs and unsupported conclusions in 16 different studies related to autism and vaccines. It includes the opinions of other authorities on these studies as well.
On-Time Vaccine Receipt in the First Year Does Not Adversely Affect Neuropsychological Outcomes (June 2010)
SafeMinds Safety First Comment to National Vaccine Program
SafeMinds Response to National Vaccine Plan of 2008 Draft (March 2009)
Latest Autism Gene Findings… Not Much (April 2009)
There’s a familiar rhythm to the most prominent autism gene hunt publications. Their authors hype their newly minted study aggressively in the media. The prestigious journals that publish them lend their imprimatur to press releases that say, “this study is a big deal.” The findings sound impressive in the press release (and the authors get plenty of time on camera and in leading newspapers to tell us how truly impressive they are). In the meantime–in papers that are so densely written that making sense of what they really say requires far more reflection than the media hype cycle permits–skillfully concealed evidence reveals the truly important new in the findings: the authors whisper quietly (if at all) that the new analysis negates the most important findings of some of the most prominent previous gene hunts, while crucial detail on their new findings is often relegated to “supplementary material” that’s not available on the publication date. Read more.
SafeMinds Sponsors and Attends 25th International Neurotoxicology Conference
NIH & AUTISM: A Case Study in Barriers to Progress in Environmental Medicine
October 2008 Authored by Sallie Bernard, Mark Blaxill and Theresa Wrangham
Read paper or poster.
SafeMinds and National Autism Association – NIEHS-Sponsored Symposium on Environmental Factors in Neurodevelopmental Disorders (August 2005)
In August 2005, a two-day symposium was held in Bethesda, Maryland on the role of environmental factors in the pathogenesis of autism spectrum disorders and related neurodevelopmental conditions. Dr. Kenneth Olden – then the director of NIEHS – conceived the idea for the conference, and the meeting was sponsored by NIEHS. Two autism research groups, the Coalition for SafeMinds and the National Autism Association, co-organized the meeting with a team of researchers they recruited to the effort.
MMR and Autism in Perspective: The Denmark Story (2004)
Authored by Carol Stott, Ph.D.; Mark Blaxill; Andrew J.Wakefield, M.B., FRCS for the Journal of American Physicians and Surgeons
Autism and related developmental disorders, once rare, are now becoming a common problem in Western countries. Although frequently catastrophic in their effects, the current crisis has come up against a “duck-and-cover” mentality from many a dusty corner of conventional medical wisdom. Read more.
Something is Rotten in Denmark (May 2004)
An Analysis of the Failures and Conflicts of Interest in Several Studies Used by IOM Vaccine Safety Committee Report. View Power Point
Generation Zero Full Analysis with Charts (2004)
Thomas Verstraeten’s First Analyses of the Link Between Vaccine Mercury Exposure and the Risk of Diagnosis of Selected Neuro-Developmental Disorders Based on Data from the Vaccine Safety Datalink: November-December 1999. Click here for full analysis with charts, click here for Generation Zero Synopsis.
Analysis and Critique of the CDC’s Handling of the Thimerosal Exposure Assessment Based on VSD Information (October 2003)
View Power Point
Analysis of the Danish Autism Registry Data Base in Response to the Hviid et al Paper on Thimerosal in JAMA (October 2003)
A large percentage of diagnosed autism cases are lost from the Danish registry each year. In the ten years preceding 2000, 815 cases were lost, more than the 710 remaining in the registry in 2000. The vast majority of those lost cases would represent older children in the 2000 registry. Since the relative risk of the Hviid study is based on finding fewer older thimerosal-exposed children than younger unexposed children, the validity of their conclusion exonerating thimerosal in autism is questionable. More likely, the finding is a result of missing records rather than true lower incidence rates among the exposed group. Read more.
Danish Thimerosal-Autism Study in Pediatrics: Misleading and Uninformative on Autism-Mercury Link (September 2003)
A report by Madsen et al. published by the American Academy of Pediatrics in their journal Pediatrics claims to provide evidence against a link between autism rates and the mercury in thimerosal, a preservative used in childhood vaccines. Unfortunately, the study analysis is full of flaws and inaccuracies, invalidating the conclusions regarding thimerosal. The study adds little of value to the scientific literature on autism and mercury. Read more.
SafeMinds Press Release: Vaccine Health Officials Manipulate Autism Records to Quell Rising Fears over Mercury in Vaccines: Safe Minds Cites Unscientific Trending Techniques and Conflicts of Interest, Call Study’s Conclusions Doubtful
Commentary on Croen et al. (2002) The Changing Prevalence of Autism in California (April 2003)
Authored by Blaxill, Baskin and Spitzer Journal of Autism and Developmental Disorders, Vol. 33, No. 2, April 2003
Lisa Croen and colleagues (Croen, Grether, Hoogstrate, & Selvin, 2002) suggest that the real incidence of autism has not increased. They propose instead that a pattern of “diagnostic substitution” has moved Californian patients who would previously have been diagnosed as mentally retarded (Croen, Grether, & Selvin, 2001) into the autism category. Their calculations purport to demonstrate that over 100% of the increase in autism from 1987–1994 is an artifact of changes in diagnostic practices. In your editorial commentary, Eric Fombonne praises the study, and claims “Croen et al. carefully analyzed the California dataset.” Read more.
Advancement in Stem Cells to Treat the Gastrointestinal System
Scientists from the University of Sheffield and University College London have made a breakthrough in understanding the formation of the enteric nervous system (ENS) of the gastrointestinal (GI) system. Dysfunction of the ENS is linked to a wide range of conditions such as Parkinson’s, Hirschprung’s disease and autism. The scientists were able to generate enteric neurons in the lab using human pluripotent stem cells and successfully implant them into mice engineered to lack an ENS. The neurons took hold in the mouse GI tract and became functional. The findings pave the way for new regenerative treatments for GI diseases in humans.
Changes Seen in Autism Symptoms and Cognition From Adolescence to Adulthood
Planning a meaningful future for a child with autism can give even the calmest parents anxiety. Especially when they are tasked with making educational, employment and/or vocational decisions while research gaps regarding autism symptoms experienced in adulthood exist. A recent SafeMinds Shares article reported on a new study that examined changes in autism symptom severities from preschool to early elementary school years. The study found around half (54.4%) of the young participant’s autism severities remained unchanged and about half of the cohort experienced a change. Twenty-eight percent saw a reduction in their autism symptoms while, sadly, 16% had their symptoms worsen.
New Study Points to Abnormal Cholesterol Metabolism Association with Autism
Using DNA analyses of brain samples, a team of scientists from Harvard, Massachusetts Institute of Technology, and Northwestern University has recently established a link between lipid dysfunction and autism. The researchers assert that dyslipidemia is a new subtype of autism, which they maintain is caused by a cluster of genes which regulate cholesterol metabolism and brain development. While confident in their findings, the authors acknowledge that their new discovery leads to new questions, two of the most critical being, how do lipid variations cause neurodevelopmental dysfunction and could repairing lipid metabolism improve disease outcomes?
New Version of Bumetanide May Treat Autism While Reducing Side Effects
talian researchers report that a new small molecule they developed has reduced autism brain pathology in a mouse model of autism. The compound was also effective in reducing the core autism-like social and repetitive behaviors in the valproic acid (VPA) mouse model of ASD.
Marijuana Use During Pregnancy Linked to Autism
A new Canadian study which examined 500,000 births in Ontario between 2007 and 2012 found that .6% of pregnant mothers used Cannabis while pregnant. Of the total birth cohort of 500,000, 1.4% of children later received an autism diagnosis. That number increased to 2.2% for children whose mothers used marijuana during pregnancy. Public health institutions in Canada and the United States have long warned pregnant women to abstain from Cannabis while pregnant.
New Study Links Autism and Melatonin System Disturbances
The majority of individuals with autism have low melatonin levels which can lead to a myriad of conditions including sleep disturbances, emotional regulation disorders, sensory processing dysfunction, inflammation throughout the body and gastrointestinal disorders. A new study out of China believes that understanding the interplay between abnormal melatonin levels and symptoms and conditions experienced at the onset of autism is associated and could lead to novel therapeutic strategies for individuals with autism spectrum disorder.
